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Test Code PTHIN Parathyroid Hormone (PTH) Intact LAB108

Performing Laboratory

UnityPoint The Finley Hospital

Test Method

Chemiluminescent Immunoassay; Roche cobas Pro 

Performance

Testing is performed Monday through Sunday.

Typically completed the same day the specimen arrives at the
testing site.

Specimen Requirement

EDTA plasma is the specimen of choice. 500μL.

Serum is also acceptable sample type as long as the tube is spun immediately after collection.

Gel tubes are acceptable.

PTH EDTA specimens are stable for 2 days at 15-25°C, 3 days at 2-8°C, and 6 months at -20°C.

PTH serum specimens are stable for 8 hours at 15-25°C, 2 days at 2-8°C, and 6 months at -20°C. 

Useful For

Detection of subfunctioning parathyroid glands (hypoparathyroidism) requires the use of a highly sensitive test in order to be able to measure PTH levels well below normal. Hyperfunctioning of the parathyroid glands results in an increased secretion of PTH (hyperparathyroidism). Primary causes are adenomas of the parathyroid glands. In secondary hyperparathyroidism the blood calcium level is low as a result of other pathological states (e.g. vitamin D deficiency).
 

The determination of PTH intraoperatively during adenoma resection in the parathyroid glands has been reported for primary hyperparathyroidism, secondary hyperparathyroidism relating to renal failure, and tertiary hyperparathyroidism post renal transplant surgery. Because PTH has a reported half‑life of 3‑5 minutes, a significant drop in PTH levels after resection of the abnormal gland or glands enables the surgeon to assess whether all hyperfunctioning parathyroid tissue has been removed from the patient.

Reference Values

15-65 pg/mL

CPT Code Information

83970: Chemistry: Parathormone (parathyroid hormone)

LOINC Code Information

2731-8 Parathyrin.Intact [Mass/Volume] In Serum Or Plasma