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Test Code MSQUAD AFP Maternal Quad Screen

Additional Codes

Epic: LAB2270


Testing is performed Monday through Sunday.

Reference Values

The Maternal Quad Screen is the second stage screening test for Down’s Syndrome, Trisome 18 and Open Neural Tube Defects. Alpha Fetoprotein (AFP), Estriol, Human Chorionic Gonadotropin (hCG) and Inhibin are reported. Also included are the risk assessment for age related Down’s Syndrome, Down’s Syndrome and Trisomy 18. An interpretation and recommended action are included.

Useful For

Detection of fetal abnormalities due to birth defects or chromosome abnomalities

CPT Information

82105 Chemistry: Alpha-fetoprotein (AFP); serum

82677 Chemistry: Estriol

84702 Other and Unlisted Chemistry Tests: Conadotropin, chorionic (hCG); quantitative

86336 Diagnostic Immunology: Inhibin A


Quantitative Chemiluminescent Immunoassay

Specimen Requirement

2 mL serum is required.

Additional Specimen Collection Instructions


  1. Collect blood in a plain, red-top tube(s) or serum gel tube(s).
  2. Allow the blood to clot, then centrifuge and remove serum (at least 2 ml) from the tube and transfer to a tube labeled with patient name or unique identifier and date of birth.
  3. Wrap the tube in absorbent material and place in a biohazard bag.
  4. Roll the specimen in the bag and place in a SHL mailer with an “A”-code self-adhesive  wrapper provided.
  5. Ship at ambient temperature.
  6. Unlabeled specimens will not be tested.
  7. Send along with the completed Iowa Maternal Screen Test Request form.
  8. The specimen must be received by SHL within 9 days of collection date.

LOINC Code Information

49085-4 First and Second Trimester Integrated Maternal Screen Panel