Sign in →

Test Code HAPT Haptoglobin LAB89

Performing Laboratory

UnityPoint The Finley Hospital

Test Method

Turbidimetric Method; Roche cobas Pro

Performance

Testing is performed Monday through Sunday.

Routine orders: Typically completed within 4 hours after the specimen arrives at the testing site.

STAT: Typically completed within 30 minutes after the specimen arrives at the testing site.

Specimen Requirement

  1. Lithium heparin plasma (green) is the specimen of choice. 0.5mL
  2. Serum (red/gold) and EDTA plasma (purple) are also acceptable sample types.
  3. It is recommended that the serum be separated from contact with cells within two hours from the time of collection.
  4. Haptoglobin specimens are stable for 3 months at 20-25°C and 8 months at 2-8°C.

Useful For

Haptoglobin is a transport and acute phase protein which is synthesized in hepatocytes. Haptoglobin binds hemoglobin in a strong haptoglobin‑hemoglobin complex (Hp‑Hb), the hemoglobin resulting from pathologically elevated hemolysis. These complexes are deposited in the hepatocytes, the deposition process having a half-life of less than 10 minutes. Hemoglobin is enzymatically metabolized and haptoglobin is liberated after approximately 3 days. Complex formation and the extremely rapid elimination from circulating blood prevent the occurrence of hemoglobinuria with excess renal loss of iron. A reduction in the level of free haptoglobin is indicative of intravascular hemolysis.

As a strong positive acute phase reactant, a hemolysis-mediated reduction or, to a certain extent, an elevation with accompanying acute inflammation can be compensated for. Indications for haptoglobin assays have been published and include the assessment of the severity and stage of intravascular hemolysis and evaluation of acute inflammatory processes.

Reference Values

30-200 mg/dL

CPT Code Information

83010 Chemistry: Haptoglobin; quantitative

LOINC Code Information

46127-7 Haptoglobin [Mass/Volume] In Serum Or Plasma By
Nephlometry