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HelpTest Code ESTRNM Estrone, Serum
Additional Codes
MAYO: E1
MAYO: LAB982
Reporting Name
Estrone, SUseful For
As part of the diagnosis and workup of precocious and delayed puberty in females and, to a lesser degree, males
As part of the diagnosis and workup of suspected disorders of sex steroid metabolism (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)
As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
Monitoring low-dose female hormone replacement therapy in postmenopausal women
Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)
Testing Algorithm
See Steroid Pathways in Special Instructions.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.2 mL
Collection Instructions:
1. Centrifuge and remove serum from red blood cells within 2 hours of draw.
2. Aliquot serum to submission container.
Additional Information: See Steroid Pathways in Special Instructions.
Specimen Minimum Volume
0.8 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Special Instructions
Reference Values
CHILDREN*
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
|
Tanner Stages# |
Mean Age |
Reference Range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-16 pg/mL |
|
Stage II |
11.5 years |
Undetectable-22 pg/mL |
|
Stage III |
13.6 years |
10-25 pg/mL |
|
Stage IV |
15.1 years |
10-46 pg/mL |
|
Stage V |
18 years |
10-60 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (± 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
|
Tanner Stages# |
Mean Age |
Reference Range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-29 pg/mL |
|
Stage II |
10.5 years |
10-33 pg/mL |
|
Stage III |
11.6 years |
15-43 pg/mL |
|
Stage IV |
12.3 years |
16-77 pg/mL |
|
Stage V |
14.5 years |
17-200 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (± 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) and Time(s) Performed
Monday through Friday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
82679
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| E1 | Estrone, S | 2258-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81418 | Estrone, S | 2258-2 |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
| Other | Serum gel or SST tube |
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)