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Test Code ALKP Alkaline Phosphatase, Total LAB112

Performing Laboratory

UnityPoint The Finley Hospital

Test Method

Enzyme Rate Method; Roche cobas Pro

Performance

Testing is performed Monday through Sunday.

Routine orders: Typically completed within 4 hours.

STAT orders: Typically completed within 30 minutes after the specimen arrives at the testing site.

Specimen Requirement

  1. Lithium heparin plasma (green) is the specimen of choice.
  2. Serum (Red/Gold) is also an acceptable sample type.
  3.  It is recommended that the serum or plasma be separated from contact with cells within 2 hours from time of collection.
  4. Alkaline phosphatase is stable at room temperature (20-25ºC) for 7 days, refrigerated (2-8ºC) for 7 days, and frozen (-20ºC) for 2 months. Frozen specimens should be thawed only once.

Useful For

Alkaline phosphatase in serum consists of four structural genotypes: the liver‑bone‑kidney type, the intestinal type, the placental type and the variant from the germ cells. It occurs in osteoblasts, hepatocytes, leukocytes, the kidneys, spleen, placenta, prostate and the small intestine. The liver‑bone‑kidney type is particularly important.

A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. It is also elevated in diseases of the skeletal system, such as Paget’s disease, hyperparathyroidism, rickets and osteomalacia, as well as with fractures and malignant tumors.

A considerable rise in the alkaline phosphatase activity is sometimes seen in children and juveniles. It is caused by increased osteoblast activity following accelerated bone growth. 

Reference Values

 

Age Female Male
0 - 14 days 83 - 248 U/L 83 - 248 U/L
15 days - < 1 yr 122 - 469 U/L 122 - 469 U/L
1 - < 10 yrs 142 - 335 U/L 142 - 335 U/L
10 - < 13 yrs 129 - 417 U/L 129 - 417 U/L
13 - < 15 yrs 57 - 254 U/L 116 - 468 U/L
15 - < 17 yrs 50 - 117 U/L 82 - 331 U/L
17 - < 19 yrs 45 - 87 U/L 55 - 149 U/L
> 19 yrs 35 - 104 U/L 40 - 129 U/L

CPT Code Information

84075 Chemistry: Phosphatase, Alkaline

LOINC Code Information

6768-6 Alkaline phosphatase [Enzymatic Activity/Volume] In
Serum Or Plasma