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Test Code VALP Valproic Acid LAB24

Performing Laboratory

UnityPoint Finley Hospital

Test Method

Homogeneous enzyme immunoassay; Roche Cobas Pro.

Performance

Testing is performed Monday through Sunday.

Routine: Typically completed within 4 hours after the specimen arrives at the testing site.

STAT: Typically completed within 1 hour after the specimen arrives at the testing site.

Specimen Requirement

0.5 ml serum (no SST) or heparinized plasma. 

Serum and plasma gel tubes are not acceptable.

Peak specimens should be collected as follows:

  • 0.5-1 Hour for syrup
  • 2-8 Hours for capsule
  • 3-7 Hours for enteric coated tablet

Trough level is collected just prior to next dose.

Serum or plasma should be separated from contact with the cells within 2 hours of collection. Specimens not centrifuged within 4 hours of collection may be rejected. Transport to the lab as soon as possible. Refrigerate the specimen if transport to the lab will be greater than 8 hours.

Useful For

Monitoring therapy

Assessing compliance

Evaluating potential toxicity

Reference Values

50.0-100.0 mcg/mL

  • Toxic Level:  >125 mcg/mL

In practice, therapeutic efficacy with this drug often requires steady-state concentrations somewhat higher than the conventional upper limit shown above.

CPT Code Information

80164 Therapeutic Drug Levels: Dipropylacetic acid
(valproic acid)