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Test Code HTGRM Thyroglobulin, Tumor Marker Reflex, Serum

Additional Codes

Mayo: HTGR

Epic: Thyroglobulin w Rflx [LAB3241]

Useful For

Reporting of accurate thyroglobulin results, depending on the antithyroglobulin antibodies status of the patient


Accurate measurement of serum thyroglobulin in patients with known or suspected antithyroglobulin autoantibodies or possible heterophile antibodies

Testing Algorithm

This test begins with the analysis of thyroglobulin antibody by immunoassay. If the thyroglobulin antibody result is negative (<1.8 IU/mL), then thyroglobulin testing will be performed by immunoassay.


If the thyroglobulin antibody result is positive (≥1.8 IU/mL), then thyroglobulin testing will be performed by mass spectrometry.

Reporting Name

Thyroglobulin Reflex to MS or IA

Specimen Type

Serum Red

Specimen Required

Patient Preparation: For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 7 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Reference Values

Thyroglobulin Antibody: <1.8 IU/mL

Day(s) Performed

TGABR, HTGT: Monday through Saturday

TGMS: Monday through Friday

Report Available

2 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HTGR Thyroglobulin Reflex to MS or IA 56536-6


Result ID Test Result Name Result LOINC Value
TGABR Thyroglobulin Antibody, S 56536-6

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HTGT Thyroglobulin, Tumor Marker, IA, S No No
TGMS Thyroglobulin, Mass Spec., S Yes No

Method Name

Immunoenzymatic Assay