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Test Code FFCAHM Congenital Adrenal Hyperplasia (CAH) Pediatric Profile 6, Comprehensive Screen

Additional Codes

MAYO: FFCAH

EPIC: LAB83877


Specimen Required


Specimen Type: Serum

Container/Tube: Red

Specimen Volume: 3.5 mL

Collection Instructions: Draw blood in a plain, red-top tube(s). (Serum gel tube is not acceptable.) Spin down and separate within 45 minutes of collection and send 3.5 mL of serum frozen in plastic vial.


Secondary ID

75305

Method Name

High Pressure Liquid Chromatography/Tandem Mass

Spectrometry (HPLC/MS-MS)

Reporting Name

CAH Profile 6

Specimen Type

Serum Red

Specimen Minimum Volume

2 mL NOTE: Minimum volume does not allow for repeat analysis.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen 90 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icteric Reject
Gel-barrier tube, non-serum sample Reject

Reference Values

Androstenedione

Units: ng/dL

Age

Range

Premature (26-28w) Day 4

63-935

Premature (31-35w) Day 4

50-449

Full Term (1-7 days)

<10-279

 

Levels decrease rapidly to <52 ng/dL after one week.

 

1-11m

<10-37

 

Androstenedione gradually decreases during the first six months to prepubertal levels.

 

Prepubertal Children

<10-17

Adult Males

44-186

Adult Females

2 -230

Females Postmenopausal

<10-93

 

Cortisol

Units: ug/dL

Age

Range

Premature (26-28w) Day 4

1.0-11

Premature (31-35w) Day 4

2.5-9.1

Full Term Day 3

1.7-14

Full Term Day 7

2.0-11

31d - 11m

2.8-23

12m - 15y (8:00 AM)

3 .0-21

 

Adults

8:00 AM

8.0-19

4:00 PM

4.0-11

 

Deoxycorticosterone (DOC)

Units: ng/dL

Age

Range

Premature (26-28w) Day 4

20-105

Premature (34-36w) Day 4

28-78

 

Newborn: Levels are markedly elevated at birth and decrease rapidly during the first week to the range of 7-49 as found in older infants.

 

1-11m

7-49

Prepubertal Children

2-34

Pubertal Children and Adults 8:00 AM

2-19

 

Dehydroepiandrosterone (DHEA)

Units: ng/dL

 

Age

Range

Premature (26-31w)

82-1484

Premature (32-35w)

56-1853

Full Term (2-7d)

41-1292

8d-5m

<948

6-12m

<136

1-5 y

<68

6-7 y

<111

8-10 y

<186

11-12 y

<202

13-14 y

<319

15-16 y

39-481

17-19 y

40-491

20 50 y

31-701

>50 y

21-402

 

11-Desoxycortisol

Units: ng/dL

Age

Range

Premature (26-28w) Day 4

110-1376

Premature (31-35w) Day 4

48-579

Newborn Day 3

13-147

1-11m

<10-156

Prepubertal 8:00 AM

20-155

Pubertal Children and Adults 8:00 AM

12-158

 

17-OH Pregnenolone

Units: ng/dL

Age

Range

Premature (26-28w) Day 4

375-3559

Premature (31-35w) Day 4

64-2380

3 Days

10-829

1-5m

36-763

6-11m

42-540

12-23m

14-207

24m-5y

10-103

6-9y

10-186

Pubertal

44-235

Adults

53-357

 

Progesterone

Units: ng/dL

Males

Age

Range

1-16y

<10-15

Adults

<10-11

 

Females

Age

Range

1-10y

<10-26

11y

<10-255

12y

<10-856

13y

<10-693

14y

<10-1204

15y

<10-1076

16y

<10-1294

 

Adult

Cycle Days

Range

1-6

<10-17

7-12

<10-135

13-15

<10-1563

16-28

<10-2555

Post Menopausal

<10

Note: Luteal progesterone peaked from 350 to 3750 ng/dL on days ranging from 17 to 23.

 

17-Alpha-Hydroxyprogesterone 17-OHP

Units: ng/dL

 

Age

Range

Premature (26-28w) Day 4

124-841

Premature (31-35w) Day 4

26-568

Full-Term Day 3

<78

 

Males: Levels increase after the first week to peak values ranging from 40-200 between 30 and 60 days. Values then decline to a prepubertal value of <91 before one year.

Prepubertal

<91

Adult Males

27-199

 

Females

1-11m

13-106

Prepubertal

<91

Adult Females

Follicular

15-70

Luteal

35-290

 

Testosterone, Total

Units: ng/dL

Age

Range

Males

Premature (26-28w) Day 4

59-125

Premature (31-35w) Day 4

37-198

Newborns

75-400

 

1-7m: Levels decrease rapidly the first week to 20-50, then increase to 60-400 between 20-60 days. Levels then decline to prepubertal range levels of <2.5-10 by seven months.

 

Females

Premature (26-28w) Day 4

5-16

Premature (31-35w) Day 4

5-22

Newborns

20-64

 

1-7m: Levels decrease during the first month to less than 10 and remain there until puberty.

 

Prepubertal Males and Females

<2.5-10

Adult Males >18 years

264-916

Adult Females

Premenopausal

10-55

Postmenopausal

7-40

 

Males

Tanner Stage

Age (years)

Range

1

<9.8

<2.5-10

2

9.8-14.5

18-150

3

10.7-15.4

100-320

4

11.8-16.2

200-620

5

12.8-17.3

350-970

 

Females

Tanner Stage

Age (years)

Range

1

<9.2

<2.5-10

2

9.2-13.7

7-28

3

10.0-14.4

15-35

4

10.7-15.6

13-32

5

11.8-18.6

20-38

 

Day(s) Performed

Monday, Wednesday

Report Available

10 to 19 days

Performing Laboratory

Esoterix Endocrinology

CPT Code Information

82633/DOC

82634/ 11-Desoxycortisol

82157/Androstenedione

82533/Cortisol

82626/DHEA

84143/17-OH-Pregnenolone

84144/Progesterone

83498/17-OH-Progesterone

84403/Testosterone

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FFCAH CAH Profile 6 Not Provided

 

Result ID Test Result Name Result LOINC Value
Z5043 Cortisol 2143-6
Z5044 Deoxycorticosterone (DOC) 1656-8
Z5045 11-Desoxycortisol 1657-6
Z5046 Dehydroepiandrosterone (DHEA) 2193-1
Z5047 17-OH Pregnenolone 6765-2
Z5048 Progesterone 2839-9
Z5049 17-Alpha-Hydroxyprogesterone 17-OHP 1668-3
Z5050 Androstenedione 1854-9
Z5051 Testosterone, Total 2986-8

Test Classification

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.