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Test Code FENRM Fentanyl Screen with Reflex, Random, Urine

Additional Codes



Useful For

Screening for drug abuse or use involving fentanyl

Profile Information

Test ID Reporting Name Available Separately Always Performed
FENS Fentanyl Screen, U Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FENTU Fentanyl w/metabolite Conf, U Yes No

Testing Algorithm

Testing begins with a screening assay. If the fentanyl screen is positive, then the liquid chromatography-tandem mass spectrometry confirmation with quantification will be performed at an additional charge.

Reporting Name

Fentanyl Screen w/Reflex, U

Specimen Type


Specimen Required

Collection Container/Tube: Plastic urine container

Submission Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 20 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Submit 20 mL in 1 plastic bottle.

3. No preservative.

Additional Information:

1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order FENTX / Fentanyl with Metabolite Confirmation, Chain of Custody, Urine.

2. If urine creatinine is required or adulteration of the sample is suspected, the following test should be requested, ADULU / Adulterants Survey, Urine or ADULT / Adulterants Survey, Urine.

3. For additional information, refer to ADULU / Adulterants Survey, Urine or ADULT / Adulterants Survey, Urine.

Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values


Screening cutoff concentration:

Fentanyl: 2 ng/mL 

Day(s) and Time(s) Performed

Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FENR Fentanyl Screen w/Reflex, U 59673-4


Result ID Test Result Name Result LOINC Value
63060 Fentanyl Screen, U 59673-4

Method Name



 If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.