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Test Code DRVTIM Dilute Russell's Viper Venom Time (DRVVT), with Reflex, Plasma

Additional Codes

MAYO: DRVI1

EPIC: LAB319


Ordering Guidance


Because no single coagulation test can identify or exclude all lupus anticoagulants (LA), and because of the complexity of testing LA, one of the following Coagulation Consultation reflexive panel procedures are recommended if clinically indicated:

ALUPP / Lupus Anticoagulant Profile, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma



Additional Testing Requirements


Serum anticardiolipin antibody testing (CLPMG / Phospholipid [Cardiolipin] Antibodies, IgG and IgM, Serum) and anti-beta-2 glycoprotein I (B2GMG / Beta-2 Glycoprotein 1 Antibodies, IgG and IgM, Serum) antibody testing should also be performed in conjunction with coagulation-based testing for lupus anticoagulants to enhance detection of different types of antiphospholipid antibodies.



Shipping Instructions


Send specimens in the same shipping container.



Specimen Required


Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing.

2. Centrifuge, remove plasma, and centrifuge plasma again.

3. Aliquot into a separate plastic vial, leaving 0.25 mL in the bottom of the centrifuged vial.

4. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, -40° C or below.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.


Secondary ID

602179

Useful For

Detecting and confirming or helping to exclude the presence of lupus anticoagulants (LA)

 

Identifying LA that do not prolong the activated partial thromboplastin time (APTT)

 

Evaluating unexplained prolongation of the APTT or prothrombin time clotting tests

 

Distinguishing LA from a specific coagulation factor inhibitor or coagulation factor deficiencies

Additional Tests

Test ID Reporting Name Available Separately Always Performed
DRVI4 DRVVT Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
DRVI2 DRVVT Mix Ratio No No
DRVI3 DRVVT Confirmation Ratio No No

Testing Algorithm

If dilute Russell's viper venom time (DRVVT) ratio is 1.20 or above, then DRVVT mix and DRVVT confirmation will be performed at an additional charge.

 

If DRVVT ratio is less than 1.20, the DRVVT mix and DRVVT confirmation will not be performed.

 

A DRVVT interpretation will always be performed.

Method Name

Optical Clot-Based

Reporting Name

DRVVT Screen Ratio, w/Reflex, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Dilute Russell's viper venom time screen ratio: <1.20

Normal ranges for children: Not clearly established, but similar to normal ranges for adults, except for newborn infants whose results may not reach adult values until 3 to 6 months of age.

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85613

85613 (if appropriate)

85613 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DRVI1 DRVVT Screen Ratio, w/Reflex, P 15359-3

 

Result ID Test Result Name Result LOINC Value
RVRI1 DRVVT Screen Ratio 15359-3

Forms

If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.