Test Code 17OHPM 17-Hydroxyprogesterone, Serum
Additional Codes
MAYO: OHPG
EPIC: LAB720
Reporting Name
17-Hydroxyprogesterone, SUseful For
The analysis of 17-hydroxyprogesterone (17-OHPG) is 1 of the 3 analytes along with cortisol and androstenedione, that constitutes the best screening test for congenital adrenal hyperplasia (CAH), caused by either 11- or 21-hydroxylase deficiency.
Analysis for 17-OHPG is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH
Testing Algorithm
See Steroid Pathways in Special Instructions.
Performing Laboratory

Specimen Type
Serum RedNecessary Information
Patient's age and sex are required.
Specimen Required
Container/Tube: Red top (serum gel/SST are not acceptable)
Specimen Volume: 0.6 mL
Specimen Minimum Volume
0.25 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum Red | Refrigerated (preferred) | 28 days | |
Frozen | 28 days | ||
Ambient | 7 days |
Special Instructions
Reference Values
Children:
Preterm infants
Preterm infants may exceed 630 ng/dL, however, it is uncommon to see levels reach 1,000 ng/dL.
Term infants
0-28 days: <630 ng/dL
Levels fall from newborn (<630 ng/dL) to prepubertal gradually within 6 months.
Prepubertal males: <110 ng/dL
Prepubertal females: <100 ng/dL
Adults:
Males: <220 ng/dL
Females
Follicular: <80 ng/dL
Luteal: <285 ng/dL
Postmenopausal: <51 ng/dL
Note: For pregnancy reference ranges, see: Soldin OP, Guo T, Weiderpass E, et al: Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry. Fertil Steril. 2005 Sept;84(3):701-710
Day(s) Performed
Monday through Friday
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83498
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
OHPG | 17-Hydroxyprogesterone, S | 1668-3 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
9231 | 17-Hydroxyprogesterone, S | 1668-3 |
Report Available
2 to 5 daysReject Due To
Gross hemolysis | OK |
Gross lipemia | Reject |
Gross icterus | OK |
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.