Sign in →

Test Code DMOGAM Monoclonal Gammopathy, Diagnostic, Serum

Additional Codes

MAYO: DMOGA

EPIC: LAB3299


Ordering Guidance


To monitor a patient with an established diagnosis of a monoclonal gammopathy, order TMOGA / Monoclonal Gammopathy, Monitoring, Serum.



Specimen Required


Patient Preparation: Fasting (12 hour) preferred but not required

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2 mL


Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

 

Renal Diagnostics Test Request (T830)

Hematopathology/Cytogenetics Test Request (T726)

Secondary ID

609782

Useful For

Screening and diagnosis of monoclonal gammopathies including analysis of free light chains

 

Assessing the risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma

Profile Information

Test ID Reporting Name Available Separately Always Performed
TMAB Therapeutic Antibody Administered? No Yes
TPE Total Protein Yes, (Order TP) Yes
SPE Protein Electrophoresis No Yes
MPTS M-protein Isotype MALDI-TOF MS, S Yes, (Order MALD) Yes
KFLCS Kappa Free Light Chain, S Yes, (Order FLCS) Yes
LFLCS Lambda Free Light Chain, S Yes, (Order FLCS) Yes
KLRS Kappa/Lambda FLC Ratio Yes, (Order FLCS) Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IFXED Immunofixation Delta and Epsilon, S Yes No

Testing Algorithm

This test includes total protein, serum protein electrophoresis, heavy and light chain typing (kappa and lambda), and quantitation of kappa and lambda free light chains.

 

If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.

 

For more information, see Multiple Myeloma: Laboratory Screening.

Method Name

TPE: Colorimetric; Biuret

SPE: Agarose Gel Electrophoresis

MPTS: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)

KFLCS, LFLCS: Turbidimetry

KLRS: Calculation

IFXED: Immunofixation

Reporting Name

Monoclonal Gammopathy Diagnostic, S

Specimen Type

Serum

Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Reference Values

TOTAL PROTEIN:

≥1 year: 6.3-7.9 g/dL

Reference values have not been established for patients that are <12 months of age.

 

PROTEIN ELECTROPHORESIS

Albumin: 3.4-4.7 g/dL

Alpha-1-globulin: 0.1-0.3 g/dL

Alpha-2-globulin: 0.6-1.0 g/dL

Beta-globulin: 0.7-1.2 g/dL

Gamma-globulin: 0.6-1.6 g/dL

An interpretive comment is provided with the report.

Reference values have not been established for patients that are <16 years of age.

 

M-PROTEIN ISOTYPE MALDI-TOF MS

No monoclonal protein detected

 

M-protein Isotype MALDI-TOF MS Flag

Negative

 

KAPPA-FREE LIGHT CHAIN

0.33-1.94 mg/dL

 

LAMBDA-FREE LIGHT CHAIN

0.57-2.63 mg/dL

 

KAPPA/LAMBDA-FREE LIGHT-CHAIN RATIO

0.26-1.65

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83521 x 2

84155

84165

0077U

86334 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DMOGA Monoclonal Gammopathy Diagnostic, S 90992-9

 

Result ID Test Result Name Result LOINC Value
TPE Total Protein 2885-2
602837 Albumin 2862-1
LFLCS Lambda Free Light Chain, S 33944-0
KLRS Kappa/Lambda FLC Ratio 48378-4
TMAB Therapeutic Antibody Administered? 98855-0
KFLCS Kappa Free Light Chain, S 36916-5
65198 M-protein Isotype MALDI-TOF MS 90990-3
606976 Flag, M-protein Isotype 94400-9
602838 Alpha-1 Globulin 2865-4
602839 Alpha-2 Globulin 2868-8
602840 Beta-Globulin 2871-2
602841 Gamma-Globulin 2874-6
602842 A/G Ratio 44429-9
602843 M spike 51435-6
602844 M spike 35559-4
602836 Impression 49296-7

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days